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Altered NAD + homeostasis has been linked to multiple diseases affecting different organs, including the brain and nervous system, liver, heart and kidney

Unlike the SmTGR U597C variant for which the flavin is observed to begin reoxidizing at 0.1 s in the presence of limiting NADPH concentration ( 1 to predict an observational rate constant of 2000 s 1 , broadly similar the conclusions drawn from the CCD data (Figure 5A)